Involvement of RAD9-Dependent Damage Checkpoint Control in Arrest of Cell Cycle, Induction of Cell Death, and Chromosome Instability Caused by Defects in Origin Recognition Complex in Saccharomyces cerevisiae

Perturbation of origin firing in chromosome replication is a possible cause of spontaneous chromosome instability in multireplicon organisms. Here, we show that chromosomal abnormalities, including aneuploidy and chromosome rearrangement, were significantly increased in yeast diploid cells with defe...

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Detalhes bibliográficos
Main Authors: Watanabe, Keiichi, Morishita, Jun, Umezu, Keiko, Shirahige, Katsuhiko, Maki, Hisaji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC118029/
https://ncbi.nlm.nih.gov/pubmed/12455955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.1.2.200-212.2002
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