Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice

Thyroid hormones [predominantly 3,5,3′-triiodo-l-thyronine (T(3))] regulate cholesterol and lipoprotein metabolism, but cardiac effects restrict their use as hypolipidemic drugs. T(3) binds to thyroid hormone receptors (TRs) α and β. TRβ is the predominant isoform in liver, whereas T(3) effects on h...

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Main Authors: Johansson, Lisen, Rudling, Mats, Scanlan, Thomas S., Lundåsen, Thomas, Webb, Paul, Baxter, John, Angelin, Bo, Parini, Paolo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177400/
https://ncbi.nlm.nih.gov/pubmed/16006512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504379102
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