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Computational prediction of native protein ligand-binding and enzyme active site sequences
Recent studies reveal that the core sequences of many proteins were nearly optimized for stability by natural evolution. Surface residues, by contrast, are not so optimized, presumably because protein function is mediated through surface interactions with other molecules. Here, we sought to determin...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1177389/ https://ncbi.nlm.nih.gov/pubmed/15998733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504023102 |
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