Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

Rat cortical astrocytes in pure culture are functionally coupled to neighboring cells via connexin (Cx) 43 gap junctions under ordinary conditions. Small fluorescent molecules such as Lucifer yellow (LY) pass between cell interiors via gap junctions, but do not enter the cells when externally applie...

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Detalhes bibliográficos
Main Authors: Contreras, Jorge E., Sánchez, Helmut A., Eugenín, Eliseo A., Speidel, Dina, Theis, Martin, Willecke, Klaus, Bukauskas, Feliksas F., Bennett, Michael V. L., Sáez, Juan C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117588/
https://ncbi.nlm.nih.gov/pubmed/11756680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012589799
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