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Inhibition of sarcoplasmic Ca(2+)-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals
BACKGROUND: Malignant hyperthermia (MH) is triggered by halogenated anaesthetics and depolarising muscle relaxants, leading to an uncontrolled hypermetabolic state of skeletal muscle. An uncontrolled sarcoplasmic Ca(2+ )release is mediated via the ryanodine receptor. A compensatory mechanism of incr...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1175794/ https://ncbi.nlm.nih.gov/pubmed/15946384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-5-8 |
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