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Inhibition of sarcoplasmic Ca(2+)-ATPase increases caffeine- and halothane-induced contractures in muscle bundles of malignant hyperthermia susceptible and healthy individuals

BACKGROUND: Malignant hyperthermia (MH) is triggered by halogenated anaesthetics and depolarising muscle relaxants, leading to an uncontrolled hypermetabolic state of skeletal muscle. An uncontrolled sarcoplasmic Ca(2+ )release is mediated via the ryanodine receptor. A compensatory mechanism of incr...

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Main Authors: Schuster, Frank, Müller, Rainer, Hartung, Edmund, Roewer, Norbert, Anetseder, Martin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175794/
https://ncbi.nlm.nih.gov/pubmed/15946384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-5-8
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