A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum

Two strains of transgenic mice have been generated that secrete into their milk a malaria vaccine candidate, the 42-kDa C-terminal portion of Plasmodium falciparum merozoite surface protein 1 (MSP1(42)). One strain secretes an MSP1(42) with an amino acid sequence homologous to that of the FVO parasi...

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Detalhes bibliográficos
Main Authors: Stowers, Anthony W., Chen, Li-how, Zhang, Yanling, Kennedy, Michael C., Zou, Lanling, Lambert, Lynn, Rice, Timothy J., Kaslow, David C., Saul, Allan, Long, Carole A., Meade, Harry, Miller, Louis H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117562/
https://ncbi.nlm.nih.gov/pubmed/11752405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012590199
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