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The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase

Uracil phosphoribosyltransferase (UPRT) is a member of a large family of salvage and biosynthetic enzymes, the phosphoribosyltransferases, and catalyzes the transfer of ribose 5-phosphate from α-d-5-phosphoribosyl-1-pyrophosphate (PRPP) to the N1 nitrogen of uracil. The UPRT from the opportunistic p...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Schumacher, Maria A., Bashor, Caleb J., Song, Minsun Hong, Otsu, Kanao, Zhu, Shuren, Parry, Ronald J., Ullman, Buddy, Brennan, Richard G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117517/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11773618/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012399599
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