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Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer
The human genetic disorder ataxia-telangiectasia (A-T) is characterized by hypersensitivity to ionizing radiation and an elevated risk of malignancy. Epidemiological data support an increased risk for breast and other cancers in A-T heterozygotes. However, screening breast cancer cases for truncatin...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117407/ https://ncbi.nlm.nih.gov/pubmed/11805335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012329699 |
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