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Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides
Here we present a combinatorial approach to evolve a stable β-hairpin fold in a linear peptide. Starting with a de novo-designed linear peptide that shows a β-hairpin structure population of around 30%, we selected four positions to build up a combinatorial library of 20(4) sequences. Deconvolution...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117354/ https://ncbi.nlm.nih.gov/pubmed/11782528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012583999 |
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