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Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae
Kinetic and spectroscopic data indicated that addition of the donor substrate hydroxypyruvate to the thiamin diphosphate (ThDP)-dependent enzyme transketolase (TK) led to the accumulation of the α-carbanion/enamine of (α,β-dihydroxyethyl) ThDP, the key reaction intermediate in enzymatic thiamin cata...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC117350/ https://ncbi.nlm.nih.gov/pubmed/11773632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022510999 |
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