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Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults including genotoxic stress. We report herein that its interaction with p53, enhanced by genotoxic stress, stabilizes the tumor suppressor thereby augmenting functions of the latter. Overexpression of ATF3 (b...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2005
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1173153/ https://ncbi.nlm.nih.gov/pubmed/15933712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600712 |
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