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Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults including genotoxic stress. We report herein that its interaction with p53, enhanced by genotoxic stress, stabilizes the tumor suppressor thereby augmenting functions of the latter. Overexpression of ATF3 (b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yan, Chunhong, Lu, Dan, Hai, Tsonwin, Boyd, Douglas D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1173153/
https://ncbi.nlm.nih.gov/pubmed/15933712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600712
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