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Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway

BACKGROUND: Diethylcarbamazine (DEC) has been used for many years in the treatment of human lymphatic filariasis. Its mode of action is not well understood, but it is known to interact with the arachidonic acid pathway. Here we have investigated the contribution of the nitric oxide and cyclooxygenas...

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Autori principali: McGarry, Helen F, Plant, Leigh D, Taylor, Mark J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1173132/
https://ncbi.nlm.nih.gov/pubmed/15932636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2883-4-4
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