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Silencing the expression of multiple Gβ-subunits eliminates signaling mediated by all four families of G proteins
The Gβγ-subunit complex derived from heterotrimeric G proteins can act to regulate the function of a variety of protein targets. We established lentiviral-based RNA interference in J774A.1 mouse macrophages to characterize the role of Gβ in G protein-coupled receptor signaling. The expression of Gβ1...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1172260/ https://ncbi.nlm.nih.gov/pubmed/15983374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503503102 |
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