A systematic RNAi screen for longevity genes in C. elegans

We report here the first genome-wide functional genomic screen for longevity genes. We systematically surveyed Caenorhabditis elegans genes using large-scale RNA interference (RNAi), and found that RNAi inactivation of 89 genes extend C. elegans lifespan. Components of the daf-2/insulin-like signali...

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Bibliografske podrobnosti
Main Authors: Hamilton, Benjamin, Dong, Yuqing, Shindo, Mami, Liu, Wenyu, Odell, Ian, Ruvkun, Gary, Lee, Siu Sylvia
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1172061/
https://ncbi.nlm.nih.gov/pubmed/15998808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1308205
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