Analysis of inhibitory action of modified U1 snRNAs on target gene expression: discrimination of two RNA targets differing by a 1 bp mismatch

The modified U1 snRNA gene can suppress expression of a target transgene. In the present study, its potential utility to inhibit a dominant negative/gain of function mutation is explored. Using a green fluorescent protein (GFP) target gene, inhibition was achieved in all cells transduced with U1anti...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Liu, Peng, Gucwa, Amy, Stover, Mary Louise, Buck, Emily, Lichtler, Alexander, Rowe, David
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2002
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117199/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034819/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.11.2329
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