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The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling.
MuSK is a receptor tyrosine kinase expressed selectively in skeletal muscle and localized to neuromuscular synapses. Agrin activates MuSK and stimulates phosphorylation and clustering of acetylcholine receptors (AChRs) at synaptic sites. We expressed wild-type or mutant MuSK in MuSK(-/-) myotubes an...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2000
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171778/ https://ncbi.nlm.nih.gov/pubmed/10619845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.1.67 |
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