RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.

Although retinoic acid receptor alpha (RARalpha) agonists induce the maturation of t(15;17) acute promyelocytic leukemia (APL) cells, drug treatment also selects leukemic blasts expressing PML-RARalpha fusion proteins with mutated ligand-binding domains that no longer respond to all-trans retinoic a...

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Detalhes bibliográficos
Main Authors: Benoit, G, Altucci, L, Flexor, M, Ruchaud, S, Lillehaug, J, Raffelsberger, W, Gronemeyer, H, Lanotte, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171764/
https://ncbi.nlm.nih.gov/pubmed/10601023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.24.7011
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