Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.

Mammalian TIF1alpha and TIF1beta (KAP-1/KRIP-1) are related transcriptional intermediary factors that possess intrinsic silencing activity. TIF1alpha is believed to be a euchromatic target for liganded nuclear receptors, while TIF1beta may serve as a co-repressor for the large family of KRAB domain-...

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Autors principals: Nielsen, A L, Ortiz, J A, You, J, Oulad-Abdelghani, M, Khechumian, R, Gansmuller, A, Chambon, P, Losson, R
Format: Artigo
Idioma:Inglês
Publicat: 1999
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171701/
https://ncbi.nlm.nih.gov/pubmed/10562550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6385
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