Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload.

Erythroid 5-aminolevulinate synthase (ALAS-E) catalyzes the first step of heme biosynthesis in erythroid cells. Mutation of human ALAS-E causes the disorder X-linked sideroblastic anemia. To examine the roles of heme during hematopoiesis, we disrupted the mouse ALAS-E gene. ALAS-E-null embryos showe...

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Main Authors: Nakajima, O, Takahashi, S, Harigae, H, Furuyama, K, Hayashi, N, Sassa, S, Yamamoto, M
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171691/
https://ncbi.nlm.nih.gov/pubmed/10562540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6282
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