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Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload.
Erythroid 5-aminolevulinate synthase (ALAS-E) catalyzes the first step of heme biosynthesis in erythroid cells. Mutation of human ALAS-E causes the disorder X-linked sideroblastic anemia. To examine the roles of heme during hematopoiesis, we disrupted the mouse ALAS-E gene. ALAS-E-null embryos showe...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171691/ https://ncbi.nlm.nih.gov/pubmed/10562540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6282 |
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