Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.

Gingipains are cysteine proteinases acting as key virulence factors of the bacterium Porphyromonas gingivalis, the major pathogen in periodontal disease. The 1.5 and 2.0 A crystal structures of free and D-Phe-Phe-Arg-chloromethylketone-inhibited gingipain R reveal a 435-residue, single-polypeptide c...

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Main Authors: Eichinger, A, Beisel, H G, Jacob, U, Huber, R, Medrano, F J, Banbula, A, Potempa, J, Travis, J, Bode, W
Formato: Artigo
Idioma:Inglês
Publicado: 1999
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171614/
https://ncbi.nlm.nih.gov/pubmed/10523290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5453
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