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Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
Gingipains are cysteine proteinases acting as key virulence factors of the bacterium Porphyromonas gingivalis, the major pathogen in periodontal disease. The 1.5 and 2.0 A crystal structures of free and D-Phe-Phe-Arg-chloromethylketone-inhibited gingipain R reveal a 435-residue, single-polypeptide c...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1999
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171614/ https://ncbi.nlm.nih.gov/pubmed/10523290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5453 |
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