Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.

Agonist-evoked cytosolic Ca(2+) spikes in mouse pancreatic acinar cells are specifically initiated in the apical secretory pole and are mostly confined to this region. The role played by mitochondria in this process has been investigated. Using the mitochondria-specific fluorescent dyes MitoTracker...

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Autores principales: Tinel, H, Cancela, J M, Mogami, H, Gerasimenko, J V, Gerasimenko, O V, Tepikin, A V, Petersen, O H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171571/
https://ncbi.nlm.nih.gov/pubmed/10487752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.18.4999
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