Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice.

Poly (ADP-ribose) polymerase-1 is a nuclear DNA-binding protein that participates in the DNA base excision repair pathway in response to genotoxic stress in mammalian cells. Here we show that PARP-1-deficient cells are defective in NF-kappaB-dependent transcription activation, but not in its nuclear...

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Главные авторы: Oliver, F J, Ménissier-de Murcia, J, Nacci, C, Decker, P, Andriantsitohaina, R, Muller, S, de la Rubia, G, Stoclet, J C, de Murcia, G
Формат: Artigo
Язык:Inglês
Опубликовано: 1999
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171519/
https://ncbi.nlm.nih.gov/pubmed/10449410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.16.4446
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