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Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.
Eukaryotic translation initiation involves recognition of the 5' end of cellular mRNA by the cap-binding complex known as eukaryotic initiation factor 4F (eIF4F). Initiation is a key point of regulation in gene expression in response to mechanisms mediated by signal transduction pathways. We ha...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171482/ https://ncbi.nlm.nih.gov/pubmed/10406811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.14.4068 |
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