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Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.
In yeast, anaphase entry depends on Pds1 proteolysis, while chromosome re-duplication in the subsequent S-phase involves degradation of mitotic cyclins such as Clb2. Sequential proteolysis of Pds1 and mitotic cyclins is mediated by the anaphase-promoting complex (APC). Lagging chromosomes or spindle...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171353/ https://ncbi.nlm.nih.gov/pubmed/10329618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.10.2707 |
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