Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.

Two distinct types of interferon, IFN-alpha/beta and IFN-gamma, commonly exhibit antiviral activities by transmitting signals to the interior of the cell via their homologous receptors. Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (...

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Bibliografiske detaljer
Main Authors: Takaoka, A, Tanaka, N, Mitani, Y, Miyazaki, T, Fujii, H, Sato, M, Kovarik, P, Decker, T, Schlessinger, J, Taniguchi, T
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171330/
https://ncbi.nlm.nih.gov/pubmed/10228162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2480
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