Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.

The WD-40 repeat protein FAN binds to a distinct domain of the p55 receptor for tumor necrosis factor (TNF) and signals the activation of neutral sphingomyelinase (N-SMase). To analyze the physiological role of FAN in vivo, we generated FAN-deficient mice by targeted gene disruption. Mice lacking a...

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Autori principali: Kreder, D, Krut, O, Adam-Klages, S, Wiegmann, K, Scherer, G, Plitz, T, Jensen, J M, Proksch, E, Steinmann, J, Pfeffer, K, Krönke, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171329/
https://ncbi.nlm.nih.gov/pubmed/10228161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2472
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