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A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast.
Exit from mitosis in all eukaroytes requires inactivation of the mitotic kinase. This occurs principally by ubiquitin-mediated proteolysis of the cyclin subunit controlled by the anaphase-promoting complex (APC). However, an abnormal spindle and/or unattached kinetochores activates a conserved spind...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171325/ https://ncbi.nlm.nih.gov/pubmed/10228157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2424 |
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