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Structure of DNA-dependent protein kinase: implications for its regulation by DNA.
DNA double-strand breaks are created by ionizing radiation or during V(D)J recombination, the process that generates immunological diversity. Breaks are repaired by an end-joining reaction that requires DNA-PKCS, the catalytic subunit of DNA-dependent protein kinase. DNA-PKCS is a 460 kDa serine-thr...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1999
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171203/ https://ncbi.nlm.nih.gov/pubmed/10064579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.5.1114 |
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