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The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

The extracellular receptor stimulated kinase ERK2 (p42(MAPK))-phosphorylated human cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced ( approximately 75%) its activity. These effects could be reversed by the action of protein phosphatase PP1. The inhibitory state of PDE4D3, enge...

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Détails bibliographiques
Auteurs principaux: Hoffmann, R, Baillie, G S, MacKenzie, S J, Yarwood, S J, Houslay, M D
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171182/
https://ncbi.nlm.nih.gov/pubmed/10022832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.4.893
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