Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors.

Streptococcal pyrogenic exotoxin A (SpeA) is a superantigen produced by Streptococcus pyogenes and is associated with severe infections characterized by rash, hypotension, multiorgan failure and a high mortality rate. In this study, an allelic form of this toxin, SpeA1, was crystallized with four mo...

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Detalhes bibliográficos
Main Authors: Papageorgiou, A C, Collins, C M, Gutman, D M, Kline, J B, O'Brien, S M, Tranter, H S, Acharya, K R
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171097/
https://ncbi.nlm.nih.gov/pubmed/9878045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.1.9
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