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G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration.

Expression of a constitutively activated version of the heterotrimeric G protein alpha-subunit Galphas results in the swelling and vacuolization of a specific subset of ventral nerve cord motoneurons of Caenorhabditis elegans. A second site modifier (sgs-1) that completely suppresses this neuronal d...

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Main Authors: Korswagen, H C, van der Linden, A M, Plasterk, R H
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170833/
https://ncbi.nlm.nih.gov/pubmed/9724641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.17.5059
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