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Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities.

The Golgi/endosome-associated Vps34 phosphatidylinositol 3-kinase is essential for the sorting of hydrolases from the Golgi to the vacuole/lysosome. Upon inactivation of a temperature-conditional Vps34 kinase, cellular levels of PtdIns(3)P rapidly decrease and it has been proposed that this decrease...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wurmser, A E, Emr, S D
Format: Artigo
Langue:Inglês
Publié: 1998
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170822/
https://ncbi.nlm.nih.gov/pubmed/9724630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.17.4930
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