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Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.
Immunoglobulin genes are assembled during lymphoid development by a series of site-specific rearrangements that are tightly regulated to ensure that functional antibodies are generated in B (but not T) cells and that a unique receptor is present on each cell. Because a common V(D)J recombinase compr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170817/ https://ncbi.nlm.nih.gov/pubmed/9707447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.16.4881 |
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