PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation.

In Escherichia coli, precursor proteins are translocated across the cytoplasmic membrane by translocase. This multisubunit enzyme consists of a preprotein-binding and ATPase domain, SecA, and the SecYEG complex as the integral membrane domain. PrlA4 is a mutant of SecY that enables the translocation...

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Autores principales: van der Wolk, J P, Fekkes, P, Boorsma, A, Huie, J L, Silhavy, T J, Driessen, A J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170699/
https://ncbi.nlm.nih.gov/pubmed/9649433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.13.3631
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