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Internal ribosome entry site-mediated translation of Smad5 in vivo: requirement for a nuclear event

Smad5 is thought to relay signals of the bone morphogenetic protein pathway. The 5′ untranslated region (5′UTR) of human Smad5 mRNA is long, has the potential to form secondary structures and contains five AUG codons. Here we show that the 5′UTR of Smad5 contains an internal ribosome entry site (IRE...

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Udgivet i:Nucleic Acids Res
Principais autores: Shiroki, Kazuko, Ohsawa, Chieko, Sugi, Natuki, Wakiyama, Motoaki, Miura, Kin-ichiro, Watanabe, Manabu, Suzuki, Yutaka, Sugano, Sumio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117063/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087169/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf408
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