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The supercoiling sensitivity of a bacterial tRNA promoter parallels its responsiveness to stringent control.
In Salmonella typhimurium, expression of the hisR locus, a tRNA operon, decreases upon inhibiting DNA gyrase. Here, the hisR promoter dependence on negative DNA supercoiling was examined in vivo and in vitro. Mutant analysis showed the sequence determinants of this dependence to lie in the region be...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170579/ https://ncbi.nlm.nih.gov/pubmed/9550733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.8.2359 |
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