Footprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA

We have studied the binding of neomycin to a 171mer RNA (ψ-RNA) from the packaging region of the LAI strain of human immunodeficiency virus type-1, HIV-1 (LAI). The RNase I footprinting studies reveal that the primary binding site for the drug is in stem–loop 1, which contains the dimer initiation s...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	McPike, Mark P., Sullivan, Julie M., Goodisman, Jerry, Dabrowiak, James C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087166/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf402
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