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Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.

The AMP-activated protein kinase (AMPK) is activated by a fall in the ATP:AMP ratio within the cell in response to metabolic stresses. Once activated, it phosphorylates and inhibits key enzymes in energy-consuming biosynthetic pathways, thereby conserving cellular ATP. The creatine kinase-phosphocre...

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Bibliografiske detaljer
Main Authors: Ponticos, M, Lu, Q L, Morgan, J E, Hardie, D G, Partridge, T A, Carling, D
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170516/
https://ncbi.nlm.nih.gov/pubmed/9501090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.6.1688
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