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Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter.
Glucocorticoids rapidly induce transcription from the mouse mammary tumour virus (MMTV) promoter via a glucocorticoid receptor (GR)-mediated chromatin disruption event. This remodelling of chromatin is transient such that upon prolonged exposure to hormone the promoter becomes refractory to glucocor...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1998
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170493/ https://ncbi.nlm.nih.gov/pubmed/9482742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.5.1454 |
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