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Gelsolin is a downstream effector of rac for fibroblast motility.
Rac, a member of the rho family of GTPases, when activated transmits signals leading to actin-based membrane ruffling in fibroblasts. Compared with wild-type fibroblasts, gelsolin null (Gsn-) dermal fibroblasts have a markedly reduced ruffling response to serum or EGF stimulation, which signal throu...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1998
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170484/ https://ncbi.nlm.nih.gov/pubmed/9482733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.5.1362 |
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