IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways.

Interleukin-10 (IL-10) limits inflammatory responses by inhibiting macrophage activation. In macrophages, IL-10 activates Stat1 and Stat3. We characterized IL-10 responses of the J774 mouse macrophage cell line, and of J774 cells expressing wild-type hIL-10R, mutant hIL-10R lacking two membrane-dist...

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Hlavní autoři: O'Farrell, A M, Liu, Y, Moore, K W, Mui, A L
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170450/
https://ncbi.nlm.nih.gov/pubmed/9463379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.4.1006
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