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Intramolecular synapsis of duplex DNA by vaccinia topoisomerase.

Complexes formed by vaccinia topoisomerase I on plasmid DNA were visualized by electron microscopy. The enzyme formed intramolecular loop structures in which non-contiguous DNA segments were synapsed within filamentous protein stems. At high enzyme concentrations the DNA appeared to be zipped up wit...

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Autori principali: Shuman, S, Bear, D G, Sekiguchi, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170262/
https://ncbi.nlm.nih.gov/pubmed/9351838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.21.6584
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