ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

Telomere loss has been proposed as a mechanism for counting cell divisions during aging in normal somatic cells. How such a mitotic clock initiates the intracellular signalling events that culminate in G1 cell cycle arrest and senescence to restrict the lifespan of normal human cells is not known. W...

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Dettagli Bibliografici
Autori principali: Vaziri, H, West, M D, Allsopp, R C, Davison, T S, Wu, Y S, Arrowsmith, C H, Poirier, G G, Benchimol, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170232/
https://ncbi.nlm.nih.gov/pubmed/9312059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.19.6018
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