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The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.
The tissue-restricted GATA-4 transcription factor and Nkx2-5 homeodomain protein are two early markers of precardiac cells. Both are essential for heart formation, but neither can initiate cardiogenesis. Overexpression of GATA-4 or Nkx2-5 enhances cardiac development in committed precursors, suggest...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1997
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170200/ https://ncbi.nlm.nih.gov/pubmed/9312027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.18.5687 |
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