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Growth factor activation of MAP kinase requires cell adhesion.
The MAP kinase pathway is a major regulator of both normal and oncogenic growth. We report that activation of the MAP kinase ERK2 by serum or purified growth factors is strongly dependent on cell adhesion to extracellular matrix proteins. This effect is specific to soluble growth factors, since susp...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
1997
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170191/ https://ncbi.nlm.nih.gov/pubmed/9312018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.18.5592 |
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