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Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping.
The zinc metalloenzyme glyoxalase I catalyses the glutathione-dependent inactivation of toxic methylglyoxal. The structure of the dimeric human enzyme in complex with S-benzyl-glutathione has been determined by multiple isomorphous replacement (MIR) and refined at 2.2 A resolution. Each monomer cons...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169964/ https://ncbi.nlm.nih.gov/pubmed/9218781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.12.3386 |
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