The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.

The LIM-only protein Lmo2, activated by chromosomal translocations in T-cell leukaemias, is normally expressed in haematopoiesis. It interacts with TAL1 and GATA-1 proteins, but the function of the interaction is unexplained. We now show that in erythroid cells Lmo2 forms a novel DNA-binding complex...

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Main Authors: Wadman, I A, Osada, H, Grütz, G G, Agulnick, A D, Westphal, H, Forster, A, Rabbitts, T H
Formato: Artigo
Idioma:Inglês
Publicado: 1997
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169933/
https://ncbi.nlm.nih.gov/pubmed/9214632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.11.3145
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