Multimerization of the adenovirus DNA-binding protein is the driving force for ATP-independent DNA unwinding during strand displacement synthesis.

In contrast to other replication systems, adenovirus DNA replication does not require a DNA helicase to unwind the double-stranded template. Elongation is dependent on the adenovirus DNA-binding protein (DBP) which has helix-destabilizing properties. DBP binds cooperatively to single-stranded DNA (s...

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Autores principales: Dekker, J, Kanellopoulos, P N, Loonstra, A K, van Oosterhout, J A, Leonard, K, Tucker, P A, van der Vliet, P C
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169742/
https://ncbi.nlm.nih.gov/pubmed/9135160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1455
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