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Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.
Nuclear protein import proceeds through the nuclear pore complex (NPC). Importin-beta mediates translocation via direct interaction with NPC components and carries importin-alpha with the NLS substrate from the cytoplasm into the nucleus. The import reaction is terminated by the direct binding of nu...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1997
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169714/ https://ncbi.nlm.nih.gov/pubmed/9135132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1153 |
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